Performance of Cpred/Cobs concentration ratios as a metric reflecting adherence to antidepressant drug therapy

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Performance of Cpred/Cobs concentration ratios as a metric reflecting adherence to antidepressant drug therapy

BACKGROUND Nonadherence is very common among subjects undergoing pharmacotherapy for schizophrenia and depression. This study aimed to evaluate the performance of the ratio of the nonlinear mixed effects pharmacokinetic model predicted concentration to observed drug concentration (ratio of population predicted to observed concentration (Cpred/Cobs) and ratio of individual predicted to observed ...

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ژورنال

عنوان ژورنال: Neuropsychiatric Disease and Treatment

سال: 2011

ISSN: 1176-6328

DOI: 10.2147/ndt.s15921